| Krack | 9 Jan 2021 | Gopichand Malineni | Ravi Teja, Shruti Haasan, Varalaxmi Sarathkumar, Samuthirakani | ₹60 cr |
| Mail | 12 Jan 2021 | Uday Gurrala | Priyadarshi Pulikonda, Harshith Malgireddy, Mani Aegurla, Gouripriya Reddy | |
| Alludu Adhurs | 14 Jan 2021 | Santhosh Srinivas | Bellamkonda Sreenivas, Nabha Natesh, Anu Emmanuel, Sonu Sood | |
| Red | 14 Jan 2021 | Kishore Tirumala | Ram Pothineni, Nivetha Pethuraj, Malvika Sharma, Amritha Aiyer | ₹31 cr |
| Cycle | 15 Jan 2021 | Aatla Arjun Reddy | Punarnavi Bhupalam, Mahat Raghavendra, Sudarshan, Swetha Varma | |
| Super Over | 22 Jan 2021 | Praveen Varma | Naveen Chandra, Chandini Chowdary, Ajay, Harsha Chemudu | |
| Bangaru Bullodu | 23 Jan 2021 | P. V. Giri | Allari Naresh, Pooja Jhaveri, Posani Krishna Murali, Ajay Ghosh | |
| 30 Rojullo Preminchadam Ela | 29 Jan 2021 | Munna | Pradeep Machiraju, Amritha Aiyer, Harsha Chemudu, Subhalekha Sudhakar | ₹13 cr |
| Amma Deevena | 29 Jan 2021 | Shiva Eturi | Aamani, Posani Krishna Murali, Ajay Ghosh | |
| Annapurnamma Gari Manavadu | 29 Jan 2021 | Narra Shiva Nageswara Rao | Baladithya, Veda Sastry, Vikram Chary, Vijayendra | |
| Cheppina Evaru Nammaru | 29 Jan 2021 | Aaryan Krishna | Aaryan Krishna, Supyardee Singh, Vikram Chary, Vijayendra | |
| Jai Sena | 29 Jan 2021 | V. Samudra | Srikanth, Sunil, Sreeram, Taraka Ratna | |
| Kalaposhakulu | 29 Jan 2021 | Chalapathy Puvvula | Vishva Karthikeya, Deepa, Gemini Suresh, Ananth | |
| Mr & Miss | 29 Jan 2021 | Ashok Reddy | Sailesh Sunny, Gnaneswari Kandregula | |
| Madhura Wines | 4 Feb 2021 | Bandi Jayakishore | Naveen Kumar Reddy, Sahasra Reddy, Tumuluri Sammohit, Kommuri Leela Venkatesh | |
| G- Zombie | 5 Feb 2021 | Aryan, Deepu | Aryan Gowra, Divya Pandey | |
| Pranavum | 5 Feb 2021 | Kumar G | Sree Mangam, Avantika Hari, Gayatri Iyer, Gemini suresh | |
| Zombie Reddy | 5 Feb 2021 | Prasanth Varma | Sajja Teja, Anandhi, Harsha Vardhan, Raghu Babu | ₹12 cr |
| FCUK: Father Chitti Umaa Kaarthik | 12 Feb 2021 | Vidya Sagar Raju | Jagapathi Babu, Ammu Abhirami, Ram Karthik, Baby Sahrashita | |
| Uppena | 12 Feb 2021 | Bucchi Babu Sana | Panja Vaisshnav Tej, Krithi Shetty, Vijay Sethupathi | ₹84 cr |
| Kapatadhaari | 19 Feb 2021 | Pradeep Krishnamoorthy | Sumanth, Nandita Swetha, Nassar, Jayaprakash | |
| Naandhi | 19 Feb 2021 | Vijay Kanakamedala | Allari Naresh, Varalaxmi Sarathkumar, Priyadarshi Pulikonda, Harish Uthaman | ₹10 cr |
| Pitta Kathalu | 19 Feb 2021 | Nag Ashwin, B. V. Nandini Reddy | Shruti Haasan, Eesha Rebba, Amala Paul, Lakshmi Manchu | |
| A: Ad Infitium | 26 Feb 2021 | Ugandhar Muni | Nithin Prasanna, Preethi Asrani, Baby Deevena, Rangadam | |
| Akshara | 26 Feb 2021 | Chinni Krishna | Nandita Swetha, Ajay Ghosh, Shakalaka Shankar, K. Sivasankar | |
| Check | 26 Feb 2021 | Chandra Sekhar Yeleti | Nithiin, Rakul Preet Singh, Priya Prakash Varrier, Sampath Raj | ₹14 cr |
| Ninnila Ninnila | 26 Feb 2021 | Ani I V Sasi | Ashok Selvan, Nithya Menon, Ritu Varma, Nassar | |
| A1 Express | 5 Mar 2021 | Dennis Jeevan Kanukolanu | Sundeep Kishan, Lavanya Tripathi, Rao Ramesh, Murali Sharma | ₹5 cr |
| April 28 Em Jarigindi | 5 Mar 2021 | Veera Swamy | Raja Ranjith, Sherry Agarwal, Tanikella Bharani, Ajay | |
| Play Back | 5 Mar 2021 | Jakka Hari Prasad | Dinesh Tej, Spandana Palli, Ananya Nagalla, Arjun Kalyan | |
| Power Play | 5 Mar 2021 | Vijay Kumar Konda | Raj Tarun, Hemal Ingle, Shamna Kasim, Prince Cecil | |
| Shaadi Mubarak | 5 Mar 2021 | Padmasri | Sagar, Drushya Raghunath, Rahul Ramakrishna | |
| Gaali Sampath | 11 Mar 2021 | Anish Krishna | Sree Vishnu, Rajendra Prasad, Tanikella Bharani, Srikanth Aiyyangar | |
| Jathi Ratnalu | 11 Mar 2021 | Anudeep K V | Naveen Polishetty, Priyadarshi Pulikonda, Rahul Ramakrishna, Murali Sharma | ₹68 cr |
| Sreekaram | 11 Mar 2021 | Kishore Reddy | Sharwanand, Priyanka Mohan, Sai Kumar, Rao Ramesh | |
| Love Life & Pakodi | 12 Mar 2021 | Jayanth Gali | Bimal Kartheek Rebba, Sanchitha Poonacha, Krishna Hebbale, Anuradha Mallikarjun | |
| Chaavu Kaburu Challaga | 19 Mar 2021 | Koushik Pegallapati | Kartikeya Gummakonda, Lavanya Tripathi, Aamani, Srikanth Iyyengar | ₹5 cr |
| Mosagallu | 19 Mar 2021 | Jeffrey Gee Chin | Vishnu Manchu, Kajal Aggarwal, Suniel Shetty, Ruhi Singh | |
| Sashi | 19 Mar 2021 | Nadikatla Srinivas Naidu | Aadhi Pudipeddi, Surbhi Puranik, Tulasi, Harsha Chemudu | |
| Aranya | 26 Mar 2021 | Prabhu Solomon | Rana Daggubati, Vishnu Vishal, Raghu Babu, Zoya Hussain | |
| Rang De | 26 Mar 2021 | Venky Atluri | Nithiin, Keerthy Suresh, Naresh, Kausalya | ₹29 cr |
| Thellavarithe Guruvaram | 27 Mar 2021 | Manikanth Gelli | Sri Simha, Harsha Chemudu, Ajay, Ravi Varma | |
| Wild Dog | 2 Apr 2021 | Ashishor Solomon | Nagarjuna, Dia Mirza, Saiyami Kher | ₹7 cr |
| Y | 2 Apr 2021 | Baalu Adusumilli | Sriram, Rahul Ramakrishna, Akshaya Chander, Gemini Suresh | |
| Vakeel Saab | 9 Apr 2021 | Venu Sriram | Pawan Kalyan, Anjali, Nivetha Thomas, Ananya Nagalla | ₹138 cr |
| Deyyam | 16 Apr 2021 | Ram Gopal Varma | Rajasekhar, Swathi Deekshith, Ahuti Prasad, Tanikella Bharani | |
| Thank You Brother | 7 May 2021 | Ramesh Rapathi | Anasuya Bharadwaj, Viraj Ashwin, Archana Ananth, Anish Kuruvilla | |
| Battala Ramaswamy Biopikku | 14 May 2021 | Rama Narayanan | Altaf Hassan, Lavanya Reddy, Satvika Jay, Shanthi Rao | |
| Cinema Bandi | 14 May 2021 | Praveen Kandregula | Vikas Vasishta, Sandeep Varanasi, Sindhu Sreenivasa Murthy, Sirivennela Yanamandhala | |
| Ek Mini Katha | 27 May 2021 | Karthik Rapolu | Santosh Shoban, Kavya Thapar, Shraddha Das, Posani Krishna Murali | |
| Ardha Shathabdham | 11 Jun 2021 | Rawindra Pulle | Karthik Rathnam, Naveen Chandra, Krishna Priya, Suhas | |
| Pachchis | 12 Jun 2021 | Sri Krishna, Rama Sai | Raamz, Swetaa Varma, Jay Chandra, Ravi Varma | |
| Crrush | 9 Jul 2021 | Ravi Babu | Krishna Burugula, Abhay Simha, Charan Sai, Ankita Manoj | |
| Narappa | 20 Jul 2021 | Srikanth Addala | Venkatesh, Priyamani, Karthik Rathnam, Rajeev Kanakala | |
| Ishq | 30 Jul 2021 | S. S. Raju | Sajja Teja, Priya Prakash Varrier | |
| Thimmarusu | 30 Jul 2021 | Sharan Koppisetty | Satyadev, Priyanka Jawalkar, Ajay, Brahmaji | |
| MAD | 6 Aug 2021 | Meneni Laxman | Rajath Raghav, Spandana Palli, Madhav Chilukuri, Swetha Varma | |
| Merise Merise | 6 Aug 2021 | Pawan Kumar K | Dinesh Tej, Shweta Avasthi, Sanjay Swarup, Guru Raj | |
| Mugguru Monagallu | 6 Aug 2021 | Abhilash reddy | Srinivasa Reddy, Dheekshith Shetty, Vennala Ramarao, Raja Ravindra | |
| SR Kalyanamandapam | 6 Aug 2021 | Sridhar Gade | Kiran Abbavaram, Priyanka Jawalkar, Sai Kumar, Anil Geela | ₹15 cr |
| Paagal | 14 Aug 2021 | Naresh Kuppili | Vishwak Sen, Simran Choudary, Nivetha Pethuraj, Murali Sharma | ₹21 cr |
| Crazy Uncles | 19 Aug 2021 | E Sathi Babu | Sreemukhi, Raja Ravindra, Mano, Bharani | |
| Kanabadutaledu | 19 Aug 2021 | Bala Raju M | Sunil, Vaishali Raj, Kancharapalem Raju, Sukranth Veerella | |
| Raja Raja Chora | 19 Aug 2021 | Hasith Goli | Sree Vishnu, Megha Akash, Sunaina, Ravi Babu | ₹21 cr |
| House Arrest | 27 Aug 2021 | Shekher Reddy Erra | Srinivasa Reddy, Saptagiri, Adhurs Raghu, Ravi Prakash | |
| Ichata Vahanamulu Niluparadu | 27 Aug 2021 | S Darshan | Sushanth, Meenakshi Chaudhary, Vennela Kishore, Priyadarshi Pulikonda | |
| Sridevi Soda Center | 27 Aug 2021 | Karuna Kumar | Sudheer Babu, Anandhi, Naresh, Satyam Rajesh | |
| Vivaha Bhojanambu | 27 Aug 2021 | Ram Abbaraju | Satya, Sundeep Kishan, Aarjavee, Srikanth Iyyengar | |
| Appudu - Ippudu | 3 Sep 2021 | Chalapathi Puvvula | Sujan, Tanishq Ranjan | |
| Asmee | 3 Sep 2021 | Sesh Kartikeya | Rushika Raj, Raja Narendra, Keshav Deepakam, Indu Kusuma | |
| Dear Megha | 3 Sep 2021 | A. Sushanth Reddy | Megha Akash, Adith Arun, Arjun Somayajula, Pavitra Lokesh | |
| Killer | 3 Sep 2021 | Chinna | Karthik Sai, Daly Shah, Neha Deshpandey | |
| Nootokka Jillala Andagadu | 3 Sep 2021 | Rachakonda Vidyasagar | Avasarala Srinivas, Ruhani Sharma | |
| Net | 10 Sep 2021 | Bhargav Macharla | Rahul Ramakrishna, Avika Gor, Vishwadev Rachakonda, Praneeta Patnaik | |
| Seetimaarr | 10 Sep 2021 | Sampath Nandi | Gopichand, Tamannaah, Digangana Suryavanshi, Bhumika Chawla | ₹19 cr |
| Tuck Jagadish | 10 Sep 2021 | Shiva Nirvana | Nani, Ritu Varma, Aishwarya Rajesh, Jagapathi Babu | |
| Gully Rowdy | 17 Sep 2021 | G. Nageswara Reddy | Sundeep Kishan, Neha Shetty, Bobby Simha, Harsha Chemudu | |
| Maestro | 17 Sep 2021 | Merlapaka Gandhi | Nithiin, Tamannaah, Nabha Natesh, Jisshu Sengupta | |
| Aakashavaani | 24 Sep 2021 | Ashwin Gangaraju | Samuthirakani, Vinay Varma, Teja Kakumanu, Prashant | |
| Alanti Sitralu | 24 Sep 2021 | Supreeth C Krishna | Shwetta Parashar, Prawin Yendamuri, Yash Puri, Tanvi Akaanksha | |
| Love Story | 24 Sep 2021 | Sekhar Kammula | Naga Chaitanya, Sai Pallavi, Rao Ramesh, Devayani | ₹62 cr |
| Maro Prastanam | 24 Sep 2021 | Johny | Tanish, Masskan Sethi, Kabir Dulhan Singh, Ravi Kale | |
| Republic | 1 Oct 2021 | Deva Katta | Sai Dharam Tej, Aishwarya Rajesh, Jagapathi Babu, Ramya Krishna | |
| The Rose Villa | 1 Oct 2021 | Hemanth | Dheekshith Shetty, Swetha Varma, Raja Ravindra | |
| Idhe Maa Katha | 2 Oct 2021 | Guru Pavan | Sumanth Ashwin, Srikanth, Bhumika Chawla, Tanya Hope | |
| Aaradugula Bullet | 8 Oct 2021 | B. Gopal | Gopichand, Nayanthara, Prakash Raj, Abhimanyu Singh | |
| Itlu Amma | 8 Oct 2021 | C. Umamaheswara Rao | MihiraVineethAruvi Bala | |
| Konda Polam | 8 Oct 2021 | Krish | Panja Vaisshnav Tej, Rakul Preet Singh, Sai Chand, Kota Srinivasa Rao | |
| Maha Samudram | 14 Oct 2021 | Ajay Bhupathi | Sharwanand, Siddharth, Aditi Rao Hydari, Anu Emmanuel | |
| Most Eligible Bachelor | 15 Oct 2021 | Bhaskar | Akhil Akkineni, Pooja Hegde, Eesha Rebba, Aamani | ₹51 cr |
| Pelli SandaD | 15 Oct 2021 | Gowri Ronanki | Roshan, Sree Leela, Rao Ramesh, Rajendra Prasad | |
| Asalem Jarigandi | 22 Oct 2021 | Nuleti Veera Raghava | Sriram, Sanchita Padukone | |
| Heads and Tales | 22 Oct 2021 | Sai Krishna Enreddy | Sunil, Srividya Maharshi, Divya Sripada, Chandni Rao | |
| Family Drama | 29 Oct 2021 | Meher Tej | Suhas, Teja Kasarapu, Sruti Meher | |
| Romantic | 29 Oct 2021 | Anil Paduri | Akash Puri, Ketika Sharma, Ramya Krishnan, Makarand Deshpande | |
| Varudu Kaavalenu | 29 Oct 2021 | Lakshmi Sowjanya | Naga Shaurya, Ritu Varma, Murali Sharma, Nadhiya | |
| Manchi Rojulochaie | 4 Nov 2021 | Maruthi | Santosh Sobhan, Mehreen Pirzada, Ajay Ghosh, Srinivasa Reddy | |
| Pushpaka Vimanam | 12 Nov 2021 | Damodara | Anand Deverakonda, Saanve Megghana, Geeth Saini, Sunil | |
| Raja Vikramarka | 12 Nov 2021 | Sri Saripalli | Kartikeya Gummakonda, Tanya Ravichandran, Sudhakar Komakula, Sai Kumar | |
| Adbhutham | 19 Nov 2021 | Mallik Ram | Teja Sajja, Shivani Rajashekar, Satya | |
| Drushyam 2: The Resumption | 25 Nov 2021 | Jeethu Joseph | Venkatesh, Meena, Kruthika Jayakumar, Esther Anil | |
| 1997 | 26 Nov 2021 | Dr. Mohan | Naveen Chandra, Dr. Mohan, Srikanth Iyengar | |
| Anubhavinchu Raja | 26 Nov 2021 | Sreenu Gavireddy | Raj Tarun, Kashish Khan, Posani Krishna Murali, Ajay | ₹5 cr |
| Akhanda | 2 Dec 2021 | Boyapati Srinu | Nandamuri Balakrishna, Pragya Jaiswal, Jagapathi Babu, Srikanth | ₹150 cr |
| Skylab | 4 Dec 2021 | Vishavak Khanderao | Nithya Menen, Satyadev, Rahul Ramakrishna, Tanikella Bharani | |
| Gamanam | 10 Dec 2021 | Sujana Rao | Shriya Saran, Suhas, Priyanka Jawalkar, Siva Kandukuri | |
| Lakshya | 10 Dec 2021 | Dheerendra Santhossh Jagarlapudi | Naga Shaurya, Ketika Sharma, Jagapathi Babu, Sachin Khedekar | ₹4 cr |
| Sundarangudu | 10 Dec 2021 | Vinay Babu | Krishna Sai, Mouryani, Isha, Mirchi Madhavi | |
| Pushpa: The Rise | 17 Dec 2021 | Sukumar | Allu Arjun, Fahadh Faasil, Rashmika Mandanna, Dhananjay | ₹350 cr |
| Shyam Singha Roy | 24 Dec 2021 | Rahul Sankrityan | Nani, Sai Pallavi, Krithi Shetty, Madonna Sebastian | ₹65 cr |
| WWW: Who Where Why | 24 Dec 2021 | K. V. Guhan | Adith Arun, Shivani Rajashekar, Priyadarshi Pulikonda, Riyaz Khan | |
| Gudaputani | 25 Dec 2021 | KM Kumar | Saptagiri, Raghu Kunche, Ananth | |
| Arjuna Phalguna | 31 Dec 2021 | Teja Marni | Sree Vishnu, Naresh, Sivaji Raja, Subbaraju | |
| Senapathi | 31 Dec 2021 | Pavan Sadineni | Rajendra Prasad, Naresh Agastya, Harsha Vardhan, Gnaneswari Kandregula | |